Forty million people use ChatGPT for health-related questions every day, making it one of the most widely used tools for health information in the world. So what is their team doing to maximize impact and minimize harm?

In this full circle episode, Halle Tecco sits down with her Rock Health co-founder Nate Gross, who also co-founded Doximity (DOCS) and is now VP of Health at OpenAI. They discuss the astonishing speed of AI progress, how models are trained for safety and accuracy, and what this technological evolution means for every part of the healthcare system.

Nearly one billion prescriptions are abandoned at the pharmacy counter every year, often because patients are blindsided by the cost.

This week, co-host Halle Tecco is joined by Wendy Barnes, President and CEO of GoodRx, to discuss the chaos of prescription drug pricing, the murky world of Pharmacy Benefit Managers (PBMs), and how digital tools are changing patient affordability. They break down the layered system of manufacturers, payers, and pharmacies that creates inconsistent pricing, and explore the current push for greater transparency.

Pete McCanna, CEO of Baylor Scott & White Health, believes that health systems are built around the wrong objective… and he has an ambitious goal to change that.

This week, Halle sits down with McCanna to unpack how one of the largest and most successful health systems in the country is shifting from a supply-driven model to one built entirely around the customer. They discuss why legacy systems operate like “walled castles,” what it takes to redesign care around real conditions instead of departments, and how Baylor Scott & White is testing a model that prioritizes access, personalization, and long-term trust over short-term profit.

Last year, his independent pharmacy spent $13 million on brand-name drugs for patients processed by the three biggest Pharmacy Benefit Managers (PBMs) which earned a profit margin of 0.01%.

In this episode, Halle speaks with Alec Ginsberg, owner and fourth-generation pharmacist at C.O. Bigelow, the oldest surviving apothecary–pharmacy in the United States. Alec is fighting against the forces squeezing independent pharmacies and charting a course for the future of the pharmacist.

Chris Klomp, Director of Medicare and Deputy Administrator of CMS, and Senior Advisor to HHS Secretary RFK Jr., has big ambitions to reshape how healthcare works in the United States.

This week, ​​Steve sits down with Klomp to discuss how his experience as a digital health entrepreneur is guiding his current role overseeing a roughly $2 trillion department. Klomp shares the government's strategy for restoring trust between providers and payers, driving down costs, and addressing a system where approximately 90% of healthcare dollars are still spent in a fee-for-service arrangement.

This week, Halle and Michael sit down for a special in-person listener Q&A to answer a range of founder questions you submitted.

Breakthrough blood tests that can flag dozens of cancers before symptoms appear are gaining momentum, yet questions remain about accuracy, equity, and how these tools will fit into routine care.

In this episode, Steve talks with Helmy Eltoukhy, co-founder and co-CEO of Guardant Health, a $14 billion publicly-traded precision oncology company. The conversation explores the science behind cell-free DNA, the rise of blood-based cancer screening, and the broader shift toward data-driven diagnostics.

When Eric Lefkofsky’s wife was diagnosed with breast cancer, it exposed how little technology and data were shaping cancer care, pushing the serial entrepreneur to build a different model.

Lefkofsky is the founder and CEO of Tempus, now a $10B publicy traded health tech company, and previously founded Groupon. At Tempus, he’s building a tech-first company applying multimodal data and AI to make diagnostics smarter and treatment decisions more tailored, starting in oncology and expanding across disease areas.

Physicians now face a world where search bars, chat apps, and large AI models are becoming many people’s first stop for health questions, long before they enter a clinic.

Former Google Chief Health Officer and national health IT leader Dr. Karen DeSalvo joins us to unpack what this shift means for clinicians, regulators, and patients, and why 15% of daily Google searches are questions no one has ever asked before.

Physicians now face a world where search bars, chat apps, and large AI models are becoming many people’s first stop for health questions, long before they enter a clinic.

Former Google Chief Health Officer and national health IT leader Dr. Karen DeSalvo joins us to unpack what this shift means for clinicians, regulators, and patients, and why 15% of daily Google searches are questions no one has ever asked before.

It has been said that we don’t have “big data” in healthcare, but instead a large amount of “small data.”

In this episode, Halle speaks with Kyle Armbrester, CEO of Datavant and former CEO of Signify Health (acquired for $8B), about why healthcare data still moves the way it did decades ago and what it will take to modernize it at scale. Kyle reflects on building and leading large health tech companies and explains how fixing data flow could reduce administrative waste, improve security, and make care easier for patients and providers alike.

This week, Steve sits down with Ankit Jain, co-founder and CEO of Infinitus Systems, to talk about why voice-based AI has become one of the most rapidly adopted tools in healthcare operations, what’s actually working in the field, and where the hype still outpaces reality. Ankit shares six years of lessons from building AI agents that handle 35-minute medical calls end to end, plus his predictions on what 2026 and 2027 will really look like as enterprises attempt to build their own agents.

Is 2026 the year that changes everything in healthcare? We’re coming off the most brutal year ever for health plans, massive budget cuts, and providers became some of the fastest adopters of AI.

Steve and Halle sit down with legendary healthcare VC Annie Lamont for their annual predictions episode to dive into 2026 predictions and trends that founders and operators should pay attention to. 

Dr. Ezekiel “Zeke” Emanuel oncologist, bioethicist, architect of the Affordable Care Act, and author of Eat Your Ice Cream joins us to share why he believes the longevity movement is overblown and how real health comes down to simplicity. In his new book, Zeke argues that instead of chasing expensive fads and wellness trends, we should focus on six straightforward habits that make life healthier and more enjoyable.

We’re closing out the year with a candid conversation about where America is headed.

For our final episode of 2025, Halle and Steve sit down with entrepreneur and former presidential candidate Andrew Yang to talk plainly about the forces reshaping American life, from rising healthcare costs and gaps in coverage to AI-driven job disruption and the strain on the social safety net. 

Many clinicians quietly wonder if there's a “next chapter” beyond the hospital walls, and an increasing number are stepping into health tech roles that didn’t exist a decade ago.

Dr. Reena Pande has lived that shift firsthand: from cardiologist at a top academic center, to early employee and CMO at AbleTo, to now leading clinician executive search at Oxeon. She joins us to unpack what it really takes for clinicians to succeed in startups, why these roles matter more than ever, and how AI is reshaping both medical training and leadership.

As millions of Americans hit the road to visit family for Thanksgiving, many will pass through, or return to, rural communities. Nearly 60 million Americans live in these areas, yet many struggle to access even basic healthcare as rural hospitals close at record rates.

This week for our 2025 recap, we’re joined by VC Emily Melton, co-founder of Threshold Ventures. Melton highlights her reflection of 2025, which splits the market into "haves and have-nots" with nothing in between, noting the concentration of venture dollars on "high flyers" and the indifference shown to established companies with respectable revenue.

As millions of Americans hit the road to visit family for Thanksgiving, many will pass through, or return to, rural communities. Nearly 60 million Americans live in these areas, yet many struggle to access even basic healthcare as rural hospitals close at record rates.

On the heels of raising $210 million at a $3.5 billion valuation, OpenEvidence is the fastest-growing physician app in history, now reaching over 40% of U.S. physicians and powers 17 million monthly clinical queries.