We don't talk enough about how hard it actually is to build a healthcare startup. Behind SmarterDx's story, now one of the biggest health AI exits to date, were 18 months without a single customer, a pivot that seemed to make no product sense, and two co-founders who went back to working as hospitalists just to get by.

In this episode, Steve gets the real story from Dr. Michael Gao and Dr. Joshua Geleris about the challenges they faced and what ultimately unlocked real growth and led to their billion+ acquisition by New Mountain Capital.

Fresh off a $240 million fundraise from Oak HC/FT and A16Z, Ambience Healthcare is on a mission to kill medical billing — and build “Iron Man suits for doctors.”

Startup accelerator and venture capital firm Y Combinator has a long history of backing early-stage healthcare startups, with a particular focus on technical founders tackling difficult problems. In this episode, YC partners Jared Friedman and Ankit Gupta share their insights on healthcare investing, the potential of AI in our industry, and why they believe young, tactical founders can play a role in reshaping healthcare.

Join us for many mic-drop moments with recording artist-turned-healthcare-investor D.A. Wallach.

Technology is transforming genetic testing and bringing hope to families facing rare diseases. GeneDx (Nasdaq: WGS) CEO Katherine Stueland sits down with Steve Kraus to share how AI is being used to crack life's most complex code and speed up diagnosis from years to days.